Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating (Statistics for Biology and Health)

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Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating (Statistics for Biology and Health) La revue

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Prediction models are important in various fields, including medicine, physics, meteorology, and finance. Prediction models will become more relevant in the medical field with the increase in knowledge on potential predictors of outcome, e.g. from genetics. Also, the number of applications will increase, e.g. with targeted early detection of disease, and individualized approaches to diagnostic testing and treatment. The current era of evidence-based medicine asks for an individualized approach to medical decision-making. Evidence-based medicine has a central place for meta-analysis to summarize results from randomized controlled trials; similarly prediction models may summarize the effects of predictors to provide individu- ized predictions of a diagnostic or prognostic outcome. Why Read This Book? My motivation for working on this book stems primarily from the fact that the development and applications of prediction models are often suboptimal in medical publications. With this book I hope to contribute to better understanding of relevant issues and give practical advice on better modelling strategies than are nowadays widely used. Issues include: (a) Better predictive modelling is sometimes easily possible; e.g. a large data set with high quality data is available, but all continuous predictors are dich- omized, which is known to have several disadvantages..


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A Brain Is Born: Exploring the Birth and Development of the Central Nervous System

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A Brain Is Born: Exploring the Birth and Development of the Central Nervous System Info

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Witness the dramatic unfolding of the human form in all its potential. Join John E. Upledger, D.O., O.M.M., as he takes you from the union of sperm and egg through the development of the complex circuitry that makes up the human brain. You'll learn about birth, growth, function and dysfunction, and how all these aspects influence physical, mental, and emotional well-being. For easy reference, he also maps out the central nervous system and the functions of all its parts. You'll discover problems that can alter brain and spinal cord development in each of the first eight weeks of pregnancy, and then monthly right through delivery. A Brain Is Born details some of the insults and injuries that can affect the newborn and commonsense ways to avoid them. Perhaps most importantly, he provides an outline of simple physical tests that can help determine the status of a baby's nervous system, including a step-by-step process for treating potential problems through the use of CranioSacral Therapy and related therapeutic approaches. This breakthrough book empowers parents with knowledge to help them make practical decisions concerning the health of their children..


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The Organic Chemistry of Drug Design and Drug Action

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The Organic Chemistry of Drug Design and Drug Action Description

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Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction.

* New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations
* Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years
* Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization.


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High-Yield Embryology (High-Yield Series)

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High-Yield Embryology (High-Yield Series) Info

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This series extracts the most important information on each topic and presents it in a concise, uncluttered fashion to prepare students for the USMLE. High-Yield means exactly that!

High-Yield Embryology, Fifth Edition provides a concentrated, efficient review of embryology material tested on the USMLE Step 1. Concepts are presented in a streamlined outline format with tables, diagrams, photos, and radiographs to clarify important material.

In response to student feedback, the Fifth Edition features:
New and updated figures
Additional USMLE-style case studies at the end of each chapter
An expanded section on early development.


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Environmental Change (Contemporary Problems in Geography)

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Environmental Change (Contemporary Problems in Geography) Description

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This concise modern survey examines the many recent interdisciplinary developments in the study of the environmental changes of the last 3 million years. It is the third edition of a well-received book which has been substantially revised to incorporate the great volume of new literature and to provide an up-to-date analysis of this increasingly important topic. The basic outline has been retained but a great deal of new information has been incorporated. The most heavily revised sections are those dealing with techniques for environmental reconstruction, glaciation in lower latitudes and the southern hemisphere, climatic changes in the twentieth century, and the causes in environmental change. These are supported by many new illustrations, new guides to further reading, and a substantially expanded bibliography. This book is intended for first- and second-year undergraduate students at university and polytechnic taking courses in physical geography, archaeology or the life sciences. Particularly relevant for courses in geomorphology or Quaternary studies..


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Statistics at Square One

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Statistics at Square One La revue

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The new edition of this international bestseller continues to throw light on the world of statistics for health care professionals and medical students.

Revised throughout, the 11th edition features new material in the areas of

• relative risk, absolute risk and   numbers needed to treat
• diagnostic tests, sensitivity, specificity, ROC curves
• free statistical software

The popular self-testing exercises at the end of every chapter are strengthened by the addition of new sections on reading and reporting statistics and formula appreciation.

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The Developing Human: Clinically Oriented Embryology with Student Consult Online Access, 9th Edition

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The Developing Human: Clinically Oriented Embryology with Student Consult Online Access, 9th Edition La revue

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The Developing Human: Clinically Oriented Embryology, by Drs. Keith L. Moore, T.V.N. Persaud, and Mark G. Torchia, delivers the world’s most complete, visually rich, and clinically oriented coverage of this complex subject. Written by some of the world’s most famous anatomists, it presents week-by-week and stage-by-stage views of how fetal organs and systems develop, why and when birth defects occur, and what roles the placenta and fetal membranes play in development. You can also access the complete contents online at www.studentconsult.com, along with 17 remarkable animations, downloadable illustrations, additional review questions and answers, and more.

• Access the full contents of the book online at www.studentconsult.com - as well as 17 remarkable animations that bring normal and abnormal embryological development to life, and hundreds of additional review questions and answers to test your mastery of the material.
• Acquire a detailed grasp of human embryology with the world’s most comprehensive, richly illustrated, and clinically oriented coverage from a cadre of leading world authorities.
• Effectively prepare for exams with review questions and answers at the end of each chapter.

• Understand all of the latest advances in embryology, including normal and abnormal embryogenesis, causes of birth defects, and the role of genes in human development.
• See how discoveries in molecular biology have affected clinical practice, including the development of sophisticated new techniques such as recumbent DNA technology and stem cell manipulation.
• Prepare for the USMLE Step 1 with clinical case presentations, highlighted in special boxes, that demonstrate how embryology concepts relate to clinical practice.

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Logistic Regression: A Self-Learning Text (Statistics for Biology and Health)

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Logistic Regression: A Self-Learning Text (Statistics for Biology and Health) La revue

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This is the third edition of this text on logistic regression methods, originally published in 1994, with its second e- tion published in 2002. As in the first two editions, each chapter contains a pres- tation of its topic in “lecture?book” format together with objectives, an outline, key formulae, practice exercises, and a test. The “lecture book” has a sequence of illust- tions, formulae, or summary statements in the left column of each page and a script (i. e. , text) in the right column. This format allows you to read the script in conjunction with the illustrations and formulae that highlight the main points, formulae, or examples being presented. This third edition has expanded the second edition by adding three new chapters and a modified computer appendix. We have also expanded our overview of mod- ing strategy guidelines in Chap. 6 to consider causal d- grams. The three new chapters are as follows: Chapter 8: Additional Modeling Strategy Issues Chapter 9: Assessing Goodness of Fit for Logistic Regression Chapter 10: Assessing Discriminatory Performance of a Binary Logistic Model: ROC Curves In adding these three chapters, we have moved Chaps. 8 through 13 from the second edition to follow the new chapters, so that these previous chapters have been ren- bered as Chaps. 11–16 in this third edition..


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Handbook of Inter-Rater Reliability: The Definitive Guide to Measuring the Extent of Agreement Among Raters

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Handbook of Inter-Rater Reliability: The Definitive Guide to Measuring the Extent of Agreement Among Raters Info

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The third edition of this book was very well received by researchers working in many different fields of research. The use of that text also gave these researchers the opportunity to raise questions, and express additional needs for materials on techniques poorly covered in the literature. For example, when designing an inter-rater reliability study, many researchers wanted to know how to determine the optimal number of raters and the optimal number of subjects that should participate in the experiment. Also, very little space in the literature has been devoted to the notion of intra-rater reliability, particularly for quantitative measurements. The fourth edition of this text addresses those needs, in addition to further refining the presentation of the material already covered in the third edition.

Features of the Fourth Edition include:

• New material on sample size calculations for chance-corrected agreement coefficients, as well as for intraclass correlation coefficients. The researcher will be able to determine the optimal number raters, subjects, and trials per subject.
• The chapter entitled “Benchmarking Inter-Rater Reliability Coefficients” has been entirely rewritten.
• The introductory chapter has been substantially expanded to explore possible definitions of the notion of inter-rater reliability.
• All chapters have been revised to a large extent to improve their readability.

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Icons of Life: A Cultural History of Human Embryos

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Icons of Life: A Cultural History of Human Embryos Description

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Icons of Life tells the engrossing and provocative story of an early twentieth-century undertaking, the Carnegie Institution of Washington's project to collect thousands of embryos for scientific study. Lynn M. Morgan blends social analysis, sleuthing, and humor to trace the history of specimen collecting. In the process, she illuminates how a hundred-year-old scientific endeavor continues to be felt in today's fraught arena of maternal and fetal politics. Until the embryo collecting project-which she follows from the Johns Hopkins anatomy department, through Baltimore foundling homes, and all the way to China-most people had no idea what human embryos looked like. But by the 1950s, modern citizens saw in embryos an image of "ourselves unborn," and embryology had developed a biologically based story about how we came to be. Morgan explains how dead specimens paradoxically became icons of life, how embryos were generated as social artifacts separate from pregnant women, and how a fetus thwarted Gertrude Stein's medical career. By resurrecting a nearly forgotten scientific project, Morgan sheds light on the roots of a modern origin story and raises the still controversial issue of how we decide what embryos mean..


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The Ontogenetic Basis of Human Anatomy: A Biodynamic Approach to Development from Conception to Birth

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The Ontogenetic Basis of Human Anatomy: A Biodynamic Approach to Development from Conception to Birth Description

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This book presents an anatomical overview of the changing form and structure of the human body. Although biomechanical embryology can be traced back to the 19th century, up until recently the most commonly accepted framework for the study of human ontogeny (development of the individual) was molecular biology, which all too frequently relied on findings from animal experiments that remained untested for humans. German embryologist and anatomist Erich Blechschmidt's research concentrates on the evidence presented by the human embryo itself. He offers a new approach to the study of early human growth as a way to shed light on the development of body build, instincts, gestures, language, mathematics, tools, and dress..


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Human Embryology and Developmental Biology: with STUDENT CONSULT Online Access

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Human Embryology and Developmental Biology: with STUDENT CONSULT Online Access La revue

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Master the concepts you need to know with Human Embryology and Developmental Biology. Dr. Bruce M. Carlson's clear explanations provide an easy-to-follow "road map" through the most up-to-date scientific knowledge, giving you a deeper understanding of the key information you need to know for your courses, exams, and ultimately clinical practice.

• Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located.
• Visualize normal and abnormal development with hundreds of superb clinical photos and embryological drawings.
• Access the fully searchable text online, view animations, answer self-assessment questions, and much more at www.studentconsult.com.

• Grasp the molecular basis of embryology, including the processes of branching and folding - essential knowledge for determining the root of many abnormalities.
• Understand the clinical manifestations of developmental abnormalities with clinical vignettes and Clinical Correlations boxes throughout.

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Practical Statistics for Medical Research (Chapman & Hall/CRC Texts in Statistical Science)

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Practical Statistics for Medical Research (Chapman & Hall/CRC Texts in Statistical Science) Info

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Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the underlying concepts of statistics, and often are divorced from the reality of conducting and assessing medical research.

Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background.

The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. The text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research..


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Introduction to Statistical Methods for Clinical Trials (Chapman & Hall/CRC Texts in Statistical Science)

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Introduction to Statistical Methods for Clinical Trials (Chapman & Hall/CRC Texts in Statistical Science) La revue

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Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial.

After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals.

Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial.

After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals.

Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials..


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Essentials of Epidemiology in Public Health, 2nd Edition

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Essentials of Epidemiology in Public Health, 2nd Edition Info

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The second edition of this best selling text is comprehensive introduction to principles applied in the practice of epidemiology in public health. Featuring the most current data and includes new problems, this revision incorporates modern ideas in epidemiological thinking that have been largely omitted in other textbooks. This edition will familiarize readers with terminology and key concepts in the design, analysis, and interpretation of epidemiological research, giving students the tools they need to critically evaluate scientific literature. Broad in scope, the text opens with five chapters covering the basic epidemiologic concepts and data sources. A major emphasis is placed on study design, with separate chapters devoted to each of the three main analytic designs: experimental, cohort, and case-control studies. Full chapters on bias, confounding, and random error, including the roll of statistics in epidemiology, ensure that students are well-equipped with the necessary information to interpret the results of epidemiologic studies. An entire chapter is also devoted to the concept of effect measure modification, an often-neglected topic in introductory textbooks. Up-to-date examples from the epidemiologic literature on diseases of public health importance are provided throughout the book..


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Screening in Chronic Disease (Monographs in Epidemiology and Biostatistics)

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Screening in Chronic Disease (Monographs in Epidemiology and Biostatistics) La revue

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This timely book presents the epidemiologic methods that can be used to determine when screening procedures are indicated, focusing on how to describe and measure changes in the natural history of disease brought on by early treatment, lead time, and prognostic selection. The author explains how to assess the usefulness of screening in reducing morbidity and mortality, and provides thorough descriptions of the experimental and case-control approaches. "An intelligent account of the role screening can play in detecting disease . . . replete with figures and tables with examples of the pros and cons of different screening tests." --Journal of the American Medical Association.


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